Does the Combination of Platelet-rich Plasma and Supervised Exercise Yield Better Pain Relief and Enhanced Function in Knee Osteoarthritis? A Randomized Controlled Trial

Three-arm randomised controlled trial comparing PRP injections, supervised exercise and their combination in mild-to-moderate knee osteoarthritis (Kellgren-Lawrence grade II-III). Of 157 patients screened, 84 were randomised (28 per arm). Outcomes included WOMAC, 40-m fast-paced walk and stair-climb tests, and SF-12 quality of life. At 24 weeks, PRP alone or combined with exercise did not provide better pain relief than exercise alone.